tapentadol vs tramadol

Tapentadol vs Tramadol

Tapentadol is a centrally acting analgesic medication used to manage moderate to severe pain. It is an opioid analgesic with a dual mechanism of action, involving mu-opioid receptor binding and norepinephrine reuptake inhibition. This combination provides effective pain relief. Tapentadol is prescribed under medical supervision due to its opioid nature and potential for side effects, and it is commonly used when other pain medications may be insufficient or not well-tolerated.

Tramadol Hydrochloride ER (Extended-Release) is a formulation of the opioid analgesic tramadol. Tramadol is used to relieve moderate to moderately severe pain. The extended-release version is designed to provide a prolonged release of the medication over time, allowing for extended pain control with less frequent dosing. Tramadol works by binding to mu-opioid receptors in the central nervous system and also inhibiting the reuptake of serotonin and norepinephrine. This dual mechanism contributes to its analgesic effects. Tramadol Hydrochloride ER is typically prescribed under medical supervision due to the potential for side effects and the risk of opioid-related adverse reactions.

Tapentadol vs tramadol

TapentadolTramadol Hydrochloride ER


Prescription onlyPrescription only
prescribed for pain relief and diabetic peripheral neuropathy.Recommended for Pain and Back Pain.
Generic  Status 
There is no cheaper version available.There is  cheaper version available
Ratings & Reviews
Tapentadol has received an average rating of 6.2 out of 10 based on a total of 428 ratings on Drugs.com. 52% of reviewers experienced a favorable outcome, whereas 29% experienced an unfavorable outcome.Tramadol Hydrochloride ER has received an average rating of 5.5 out of 10 based on a total of 14 ratings on Drugs.com. 21% of reviewers experienced a favorable outcome, whereas 21% experienced an unfavorable outcome.
Drug Class
Opioids (narcotic analgesics)Opioids (narcotic analgesics)
Brand Names
Nucynta, Nucynta EROther tramadol brands: ConZip, Qdolo
Half Life [A drug’s half-life is the time it takes for its plasma concentration to fall to half of its original value]
4 hours5.2 hours
First Approval Date
November 20, 2008September 2005
Dosage Form(s) Available
Immediate-Release Tablets (IR) relieve pain quickly. To treat pain, they are given every 4–6 hours. Common strengths include 50, 75, and 100 mg.

Extended-Release Tablets (ER): Extended-release versions deliver the drug slowly, reducing dosage. Once every 12 hours, ER pills are administered. Common strengths are tapentadol 50mg, tapentadol 100mg, tapentadol 150mg, tapentadol 200mg, and 250 mg.

Tapentadol is also available as a liquid oral solution. Patients who have trouble swallowing pills may benefit. Dosing spoons or syringes measure oral solution.

Extended-Release Tablets (ER): Tramadol ER is often available in tablet form. These tablets are formulated to release the medication slowly over an extended period, typically requiring dosing every 12 to 24 hours. Common strengths include 100 mg, 200 mg, and 300 mg.
Disease Interactions
Impairment of gastrointestinal motility

Communicable gastroenteritis

Liver ailment

Premature child growth

Acute excess with alcohol

Tobacco dependence

Obstruction of the gastrointestinal tract

Hypotension (HF)

The intracranial stress

Affective respiratory depression

Abdominal spasm

Renal impairment

Seizures are pathological

Renal retention of the urine

Obstruction of the gastrointestinal tract

Acute excess with alcohol

Drug habit

Affective respiratory depression

gastrointestinal disorders

Hypoglycemia (HG)

Hypotension (HF)

The intracranial stress

Liver illness

Renal impairment

Seizures are pathological

Behaving suicidal

Side effects
Common side effects:


Nausea, vomiting, constipation, dizziness, headache, sleepiness.

Less common or rare:


Sweating, dry mouth, loss of appetite, weight loss, insomnia, increased heart rate, mood changes.

Serious side effects (seek medical attention):


Shallow breathing, chest pain, severe dizziness, confusion, seizures.

– Common side effects:


– Dizziness

– Headache

– Constipation

– Sweating


– Less common:

– Vomiting

– Fatigue

– Dry mouth

– Diarrhea

– Nervousness


– Rare but serious:

– Seizures

– Serotonin syndrome

– Allergic reactions (rash, swelling, difficulty breathing)


In conclusion, both tapentadol and tramadol (Tramadol Hydrochloride ER) are opioid analgesics used to manage moderate to severe pain. Tapentadol offers a dual mechanism of action by binding to mu-opioid receptors and inhibiting norepinephrine reuptake, while tramadol functions through mu-opioid receptor binding and serotonin/norepinephrine reuptake inhibition. The extended-release formulation of tramadol provides prolonged pain relief with less frequent dosing. However, both medications carry potential side effects and should be used under the guidance of healthcare professionals due to the risks associated with opioid use, including the potential for addiction and other adverse reactions. The choice between tapentadol and tramadol depends on individual patient factors and the specific characteristics of the pain being treated.

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