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History of Tapentadol

In the United States the Food and Drug Administration (FDA) approved tapentadol in 2008 using its new drug fast-track program. FDA fast-track status was based on positive results from a phase III trial which led to tapentadol being classified as a schedule II controlled substance by the U.S. Drug Enforcement Administration in 2009; for a time products containing tapentadol could only be prescribed through certified physicians who had enrolled in a special DEA registration.  Overnight Delivery with Bitcoin and PayPal with Affordable Prices and Fast Shipping With 2-3 Days From USA.

In the late 1980s, Grünenthal developed tapentadol 100mg, a chemical analog of tramadol, by combining tramadol and its active metabolites. The goal was to create a single molecule with similar μ-opioid analgesic properties as tramadol but with less norepinephrine reuptake inhibition, decreased risk for stimulant side effects, more favorable chemical stability, and fewer metabolites

The chemical name of tapentadol is morphinan-6-ol,10,11-dihydro-N-methyl-6-(1-methylbutyl)-,(5α,14α)- (phenanthrene-diol analogue), a white crystalline powder that is practically insoluble in water and soluble in alcohol and in chloroform.

It has a melting point of 265 – 268°C and an oral activity that is similar to codeine


Buy Tapentadol 100mg Online was discovered between 1988 and 1989 by scientists working at CIBA. Phase I trials were conducted in 1990, phase II trials in 1993, and a phase III trial program began in 1995 CIBA partnered with Grünenthal to bring tapentadol 100mg to market and the drug was approved for sale in Germany in 2002.


Tapentadol 100mg is quickly absorbed, with a maximum serum concentration (Cmax) usually occurring between 1.25 and 1.5 hours.Tapentadol’s Cmax and area-under-the-curve (AUC) values increased proportionally above the 50- to 150-mg dosing range, indicating linear pharmacokinetics. Tapentadol’s AUC and Cmax rise by 25% and 16%, respectively, after a high-fat, high-calorie diet.

Buy Tapentadol 100mg Online has a long elimination half-life of 15 to 17 hours.12 Tapentadol 100mg elimination is almost exclusively via non-renal pathways; renal clearance (2.4 mL/minute) is less than 5% of total body clearance and does not contribute significantly to the elimination of tapentadol and N-demethylated metabolites.14

The pharmacokinetic profile of tapentadol HCl is not affected by gender or race (African Americans and Caucasians) following oral administration. No dose adjustment is necessary for patients with mild or moderate renal impairment, but because there are no clinical trials specifically conducted in patients with severe renal impairment (creatinine clearance less than 30 mL/min, see CONTRAINDICATIONS), tapentadol 100mg HCl should be used with caution in these patients .

What is Tapentadol ?

TAPENTADOL is for patients who need around-the-clock pain relief that can last for as long as 12 hours. It is a prescription medication that comes in tablet form. TAPENTADOL was formerly marketed under the brand name Nuycnta in USA

Important Note : You can’t take this drug without the OK of your doctor. Do not take more than the amount of TAPENTADOL that your doctor has told you to, either all at once or over time.

How Effective Is Tapetandol For Pain Management ?

Opioids are effective in the management of moderate to severe pain in opioid-naïve patients as well as patients with chronic pain. Tapentadol is a newly developed long-acting analgesic with a novel chemical structure that is a member of the morphinan series and has been found to have the following pharmacological properties: agonist activity at μ-opioid receptors, negligible affinity for δ-opioid receptors, κ-opioid receptors, noradren

Study results: The tapentadol IR 50 and 75 mg doses were more effective than 10 mg of oxycodone IR in relieving pain, but tapentadol 100mg showed no better efficacy than 10 mg oxycodone . Tapentadol was better tolerated than oxycodone, with similar incidence and severity of GI AEs for tapentadol 50 and 75 mg and lower nervous system AE incidence for tapentadol 75

Pretreatment with tapentadol 100mg IR provided a significantly better for Severe Pain Management analgesic response than the 50 mg dose but had more gastrointestinal AEs. Tapentadol 100mg IR showed similar incidence of gastrointestinal AEs but higher nervous system AEs compared to oxycodone 10 mg IR. Tapentadol 50mg, 75mg and  Tapentadol 100mg IR can provide significant relief for moderate to severe pain, with similar efficacy

Why Choose Tapentadol

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Our specially crafted packaging provides an extra layer of privacy between you and your customers. Due to the nature of these items

Pros and cons of Aspadol 100 mg (tapentadol)



Can I Buy Tapentadol Online ?

Buy Tapentadol 100mg Online for pain relief

If you are having a problem with your some medical condition and you have been prescribed to Tapentadol 100mg. Then we would suggest you don’t wait for now for your medical issues when you can buy Tapentadol 100mg online from our store and save the time, money and efforts. Also note that Tapentadol is just like any other prescription medication. So it is necessary that you need to consult a doctor if you are under any medication or on any other medications also.

Depending on the needs of our buyers, we offer a variety of payment methods. If you want to buy Tapentadol online with a prepaid advance payment order then you can go for it, but if you don’t want to share your card information and bank information then you can easily buy Tapentadol with PayPal.

Cost of Tapentadol online (Nuycnta )

Cost for a supply of 100 tablets from a mail-order pharmacy at is $1,024. If you had a Discount you can Apply that. The cost for a supply of 100 tablets from an online pharmacy listed on GoodRx is about $1,040. Even if you apply the discount on it the Price still not come below $800 USD for a month supply of Tapentadol.

But Tapentadol 100 mg also name as Aspadol 100 mg are available at very cheap Price as Compare to Brand Name the cost of Aspadol 100mg for a supply of 100 tablets from pharmacy at is $200. So You are almost Saving around $800 per month for getting relief from Life Threating Pain

Pharmacist Advise FOR TAPENTADOL 100 MG (NUYCNTA)

Frequently Asked Questions

In every country, if you have a prescription from a doctor or another qualified medical professional, you can legally buy Tapentadol online. In some countries, Tapentadol is available without a prescription.

Tapentadol can relieve moderate to severe pain, but only when prescribed, used as directed, and under the guidance of a healthcare professional. One reason is that the medicine has some potential side effects and potential risks associated with their use, including addiction, overdose, and respiratory .

The initial loading dose may not be required in patients over 65 years of age, although it has been found to be a safe and effective dosage in such people as well.

Tapentadol is a Schedule II medication. That indicates that it has a high potential for abuse, and may also be addictive.

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